Bacterial overgrowth syndrome in adolescents with Сhronic viral hepatitis C

There is a close relationship between intestine and liver, so-called ‘gut liver’ axis, especially in patients suffered from chronic liver diseases with significant degree of fibrosis. Small intestinal bacterial overgrowth disturbance the microbiota composition lead to an increase permeability epithelium, development endotoxinemia, activation pro-inflammatory cytokines and, as consequence, additional damage hepatocytes. Objective. To estimate incidence syndrome (BOS) small adolescents hepatitis C (CHC), identify interaction this cytolytic activity, Materials methods. group 33 aged 12—17 years old CHC. All children underwent hydrogen breath test lactulose. The fibrosis was assessed by results elastography (Fibroscan), activity determined level alanine transaminase serum. Results. frequency BOS 81.8% study group. As result correlation analysis, no found (criterion χ2= 0.914, p > 0.05). Also, there excessive contamination tissue 0.914,p> Conclusion. CHC occurs much more often than adults. However, severity fibrotic changes liver.